EMPreSS (Epithelial Mesenchymal Precision Spectrum Scoring) is a new system to assess the epithelial and mesenchymal states from the concept of a spectrum beyond the traditional binary perspective. Our fundamental questions are: What makes the epithelial, epithelial? What is the precise estimation of “mesenchymality”? What is the fluidity of the interchange among different states? Acknowledging the existence of EMT as a spectrum, solving the heterogeneity of EMT thus becomes an inevitable task. Our lab takes several approaches to dissect the heterogeneity of EMT from multiple dimensions: (1) the fluidity of transition; (2) the genome architecture; (3) the spatial context.
